Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs
نویسندگان
چکیده
Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a promising approach enhance the delivery of such drugs. Moreover, encapsulation within capsules provide convenient dosage form for administration. The techniques are optimized ensure uniform drug content efficient efficiency. Several investigations demonstrated that significantly improved solubility dissolution rate poorly compared non-lipid formulations. Additionally, protected against degradation its stability. Overall, incorporating represents strategy enhancing with improvement solubility, dissolution, stability, bioavailability, overcoming challenges associated challenging molecules. review focussed brief on utilization lipids capsule improve efficacy soluble,
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ژورنال
عنوان ژورنال: Frontiers in Drug Delivery
سال: 2023
ISSN: ['2674-0850']
DOI: https://doi.org/10.3389/fddev.2023.1232012